Cylinders vs. spheres: biofluid shear thinning in driven nanoparticle transport.

ABSTRACT: Increasingly, the research community applies magnetophoresis to micro and nanoscale particles for drug delivery applications and the nanoscale rheological characterization of complex biological materials. Of particular interest is the design and transport of these magnetic particles through entangled polymeric fluids commonly found in biological systems. We report the magnetophoretic transport of spherical and rod-shaped particles through viscoelastic, entangled solutions using lambda-phage DNA (λ-DNA) as a model system. In order to understand and predict the observed phenomena, we fully characterize three fundamental components: the magnetic field and field gradient, the shape and magnetic properties of the probe particles, and the macroscopic rheology of the solution. Particle velocities

SUBMITTER: Cribb JA 

PROVIDER: S-EPMC3858002 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature