Study on incompatibility of traditional chinese medicine: evidence from formula network, chemical space, and metabolism room.

ABSTRACT: A traditional Chinese medicine (TCM) formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical space and a TCM metabolism room under the theory of chemical space. The properties of chemical space and metabolism room were calculated and analyzed. The properties of the medicine pairs in "eighteen antagonisms and nineteen mutual inhibitors," an ancient rule for TCM incompatibility, were studied based on the TCM formula network, chemical space, and metabolism room. The results showed that the properties of these incompatible medicine pairs are different from those of the other TCM based on th

SUBMITTER: Long W 

PROVIDER: S-EPMC3858019 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature