HIV-1 transmission during early infection in men who have sex with men: a phylodynamic analysis.

ABSTRACT:

Background

Conventional epidemiological surveillance of infectious diseases is focused on characterization of incident infections and estimation of the number of prevalent infections. Advances in methods for the analysis of the population-level genetic variation of viruses can potentially provide information about donors, not just recipients, of infection. Genetic sequences from many viruses are increasingly abundant, especially HIV, which is routinely sequenced for surveillance of drug resistance mutations. We conducted a phylodynamic analysis of HIV genetic sequence data and surveillance data from a US population of men who have sex with men (MSM) and estimated incidence and transmission rates by stage of infection.

Methods and findings

We analyzed 662 HIV-1 subtype B sequ

SUBMITTER: Volz EM 

PROVIDER: S-EPMC3858227 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature