Graph theory analysis of cortical-subcortical networks in late-life depression.

ABSTRACT:

Objectives

Late-life major depression (LLD) is characterized by distinct epidemiologic and psychosocial factors, as well as medical comorbidities that are associated with specific neuroanatomical differences. The purpose of this study was to use interregional correlations of cortical and subcortical volumes to examine cortical-subcortical structural network properties in subjects with LLD compared with healthy comparison subjects.

Methods

This was a cross-sectional neuroimaging study conducted in the general community. We recruited 73 healthy elderly comparison subjects and 53 subjects with LLD who volunteered in response to advertisements. Brain network connectivity measures were generated by correlating regional volumes after controlling for age, gender, and intracranial v

SUBMITTER: Ajilore O 

PROVIDER: S-EPMC3858393 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature