Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program?

ABSTRACT:

Objective

This study aims to examine whether blood pressure reductions differ by estrogen use among overweight glucose-intolerant women.

Methods

We conducted a secondary analysis of Diabetes Prevention Program postmenopausal participants who used oral estrogen with or without progestogen at baseline and 1-year follow-up (n = 324) versus those who did not use oral estrogen with or without progestogen at either time point (n = 382). Changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) were examined by randomization arm (intensive lifestyle change [ILS], metformin 850 mg twice daily, or placebo). Associations between changes in blood pressure and changes in sex hormone-binding globulin, estradiol, testosterone, and dehydroepiandrosterone were also examine

SUBMITTER: Kim C 

PROVIDER: S-EPMC3858523 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature