Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.

ABSTRACT:

Importance

Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous studies have suggested that the genetic factors predisposing to excess cardiovascular risk may be different in diabetic and nondiabetic individuals.

Objective

To identify genetic determinants of CHD that are specific to patients with diabetes.

Design, setting, and participants

We studied 5 independent sets of CHD cases and CHD-negative controls from the Nurses' Health Study (enrolled in 1976 and followed up through 2008), Health Professionals Follow-up Study (enrolled in 1986 and followed up through 2008), Joslin Heart Study (enrolled in 2001-2008), Gargano Heart Study (enrolled in 2001-2008), and Catanzaro Study (enrolled in 2004-2010). Included were a total of 1517 CHD

SUBMITTER: Qi L 

PROVIDER: S-EPMC3858847 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature