Long-term multivitamin supplementation and cognitive function in men: a randomized trial.

ABSTRACT:

Background

Despite widespread use of multivitamin supplements, their effect on cognitive health-a critical issue with aging-remains inconclusive. To date, no long-term clinical trials have studied multivitamin use and cognitive decline in older persons.

Objective

To evaluate whether long-term multivitamin supplementation affects cognitive health in later life.

Design

Randomized, double-blind, placebo-controlled trial of a multivitamin from 1997 to 1 June 2011. The cognitive function substudy began in 1998. Up to 4 repeated cognitive assessments by telephone interview were completed over 12 years. (ClinicalTrials.gov: NCT00270647) SETTING: The Physicians' Health Study II.

Patients

5947 male physicians aged 65 years or older.

Intervention

Daily multivitami

SUBMITTER: Grodstein F 

PROVIDER: S-EPMC3858850 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature