Hekate: software suite for the mass spectrometric analysis and three-dimensional visualization of cross-linked protein samples.

ABSTRACT: Chemical cross-linking of proteins combined with mass spectrometry provides an attractive and novel method for the analysis of native protein structures and protein complexes. Analysis of the data however is complex. Only a small number of cross-linked peptides are produced during sample preparation and must be identified against a background of more abundant native peptides. To facilitate the search and identification of cross-linked peptides, we have developed a novel software suite, named Hekate. Hekate is a suite of tools that address the challenges involved in analyzing protein cross-linking experiments when combined with mass spectrometry. The software is an integrated pipeline for the automation of the data analysis workflow and provides a novel scoring system based on principles of

SUBMITTER: Holding AN 

PROVIDER: S-EPMC3859183 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature