Epigenetic basis of regeneration: analysis of genomic DNA methylation profiles in the MRL/MpJ mouse.

ABSTRACT: Epigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. To investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms and the MRL/MpJ mouse as a model of mammalian regeneration known to exhibit enhanced regeneration response in different organs. We report the comparative analysis of genomic DNA methylation profiles of the MRL/MpJ and the control C57BL/6J mouse. Methylated DNA immunoprecipitation followed by microarray analysis using the Nimblegen '3 × 720 K CpG Island Plus RefSeq Promoter' platform was applied in order to carry out genome-wide DNA methylation profiling covering 20 404 promoter regions. We identified hundr

SUBMITTER: Gornikiewicz B 

PROVIDER: S-EPMC3859327 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature