Recall responses to tetanus and diphtheria vaccination are frequently insufficient in elderly persons.

ABSTRACT:

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Demographic changes and a more active life-style in older age have contributed to an increasing public awareness of the need for lifelong vaccination. Currently many older persons have been vaccinated against selected pathogens during childhood but lack regular booster immunizations. The impact of regular vaccinations when started late in life was analyzed in an open, explorative trial by evaluating the immune response against tetanus and diphtheria in healthy older individuals. 252 persons aged above 60 years received a booster vaccination against tetanus, diphtheria, pertussis and polio and a subcohort (n=87) was recruited to receive a second booster vaccination against tetanus, diphtheria and pertussis 5 years later. The percentage of unprotected individuals at the ti

SUBMITTER: Weinberger B 

PROVIDER: S-EPMC3859625 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature