Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation.

ABSTRACT: The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies. However, the mechanism of ubiquitination site selection remains elusive because of the complicated sequence pattern flanking the ubiquitination sites. In this study, we perform a systematic analysis of 1,330 ubiquitination sites in 505 protein structures and quantify the significantly high accessibility and unexpectedly high centrality of human ubiquitination sites. Further analysis suggests that the higher centrality of ubiquitination sites is associated with the multi-functionality of ubiquitination sites, among which protein-protein interaction sites are common tar

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC3859641 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature