Specimen-specific predictions of contact stress under physiological loading in the human hip: validation and sensitivity studies.

ABSTRACT: Hip osteoarthritis may be initiated and advanced by abnormal cartilage contact mechanics, and finite element (FE) modeling provides an approach with the potential to allow the study of this process. Previous FE models of the human hip have been limited by single specimen validation and the use of quasi-linear or linear elastic constitutive models of articular cartilage. The effects of the latter assumptions on model predictions are unknown, partially because data for the instantaneous behavior of healthy human hip cartilage are unavailable. The aims of this study were to develop and validate a series of specimen-specific FE models, to characterize the regional instantaneous response of healthy human hip cartilage in compression, and to assess the effects of material nonlinearity, inhomogen

SUBMITTER: Henak CR 

PROVIDER: S-EPMC3859708 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature