Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study.

ABSTRACT:

Background

  Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex aetiology. The identification of candidate intermediate phenotypes that are both heritable and genetically linked to ADHD may facilitate the detection of susceptibility genes and elucidate aetiological pathways. Very low-frequency (VLF; <0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder.

Methods

  Direct-current (DC)-EEG was recorded during a cognitive activation condition in 30 monozygotic and dizygotic adolescent twin pairs concordant or discordant for high ADHD symptom scores, and 37 monozyg

SUBMITTER: Tye C 

PROVIDER: S-EPMC3859923 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature