Potential prognostic biomarkers of pancreatic cancer.

ABSTRACT:

Objectives

We evaluated whether pancreatic main duct fluid can provide protein biomarkers with prognostic value.

Methods

Mass spectrometry proteomics was applied to as little as 20µL of fluid collected at the time of tumor surgical resection. Biomarker proteins identified for 27 patients were correlated with clinical outcomes.

Results

Thirteen patients had pancreatic ductal adenocarcinomas, 4 had intraductal papillary mucinous neoplasm with in situ adenocarcinoma, 5 had ampullary adenocarcinomas, 2 had intraductal papillary mucinous neoplasms, and 3 had benign diseases. In pathologic stage II or higher pancreatic ductal adenocarcinoma, moderate or high expression of S100A8 or S100A9 proteins was associated with a median disease recurrence-free survival of 5.8 months c

SUBMITTER: Chen KT 

PROVIDER: S-EPMC3859961 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature