Factor V Leiden mutation is not a predisposing factor for acute coronary syndromes.

ABSTRACT:

Background

The prevalence of Coronary artery disease (CAD) in India has increased considerably over the past few years and could become the number one killer disease if interventions are not done. Factor V Leiden (FVL) mutation and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis. This warrants the investigations for thrombophilia in myocardial infarction patients in India.

Methods

The study cohort consisted of 51 patients aged below 50 years presenting with acute coronary syndromes. In both patient group and normal individuals the major risk factors Protein C deficiency, Protein S deficiency, anticardiolipin antibodies, Fibrinogen and Lipoprotein [a] were studied. Factor V Leiden (FVL) G1691A mutation in both co

SUBMITTER: Himabindu G 

PROVIDER: S-EPMC3860758 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature