Dataset Information

Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives.

ABSTRACT: Immunotherapy of malignant gliomas with autologous dendritic cells (DCs) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10-15% of the several hundred vaccinated patients represent children, making pediatric glioma patients the largest uniform pediatric vaccination cohort so far. In general, DC vaccination in malignant gliomas has been shown to be safe and several studies with a non-vaccinated control group could clearly demonstrate a survival benefit for the vaccinated patients. Interestingly, children and adolescents below 21 years of age seem to benefit even more than adult patients. This review summarizes the findings of the 25 clinical trials published so far and gives a perspective how DC vaccination could be implemented as part of multimodal therapeutic strategies in the near future.

SUBMITTER: Eyrich M

PROVIDER: S-EPMC3860891 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives.

Eyrich Matthias M Rachor Johannes J Schreiber Susanne C SC Wölfl Matthias M Schlegel Paul G PG

Frontiers in pediatrics 20130610

Immunotherapy of malignant gliomas with autologous dendritic cells (DCs) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10-15% of the several hundred vaccinated patients represent children, making pediatric glioma patients the largest uniform pediatric vaccination cohort so far. In general, DC vaccination in malignant gliomas has been shown to be safe and ...[more]

PMID: 24400258

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Project description:ObjectivesRobust data on nutrition are essential to realise the right to nutrition for every child. Created in 2009, UNICEF's Nutrition Dashboard (NutriDash) collects nutrition programme information from 125 countries. An in-depth review of NutriDash was conducted to understand its strengths and identify key actions to increase its effectiveness and efficiency.MethodsAdapting the Centres for Disease Control and Prevention updated guidelines for evaluating public health surveillance systems, a mixed-methods approach was used. A questionnaire was designed to capture information on key attributes of NutriDash and disseminated to UNICEF country offices for quantitative feedback on user experiences. Structured key informant interviews were held with internal and external stakeholders to gain qualitative perceptions on data generated from NutriDash. Analysis involved producing frequency distributions for the questionnaire data and performing thematic analyses on interview data.ResultsA total of 53 respondents completed the questionnaire (42% response rate), representing 48 countries and good regional geographic representation. Most respondents (96%) worked in UNICEF country offices. The percentages of participants who agreed or strongly agreed with each attribute of the NutriDash system were as follows: acceptability: 71%, stability: 68%, simplicity; 63%, data quality: 60%, flexibility: 58% and usefulness: 43%. Internal and external stakeholders commented on the value of NutriDash; its use ranging from nutrition global trend monitoring for programme planning to producing reports and dashboards. Key themes derived from this review as areas for improvement included communication, access to data and data quality.ConclusionsThis review has identified key themes that will inform improvements to NutriDash and form a baseline for future periodic reviews to continuously enhance the system to improve availability of timely quality nutrition programme data. UNICEF will continue to engage with countries, key partners and governments to improve the NutriDash data value chain and ensure the right to nutrition for every child.

Dataset Information

Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives.

Publications

Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives.

Similar Datasets

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