Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance.

ABSTRACT: Sustained or repeated exposure to sedating drugs, such as alcohol, triggers homeostatic adaptations in the brain that lead to the development of drug tolerance and dependence. These adaptations involve long-term changes in the transcription of drug-responsive genes as well as an epigenetic restructuring of chromosomal regions that is thought to signal and maintain the altered transcriptional state. Alcohol-induced epigenetic changes have been shown to be important in the long-term adaptation that leads to alcohol tolerance and dependence endophenotypes. A major constraint impeding progress is that alcohol produces a surfeit of changes in gene expression, most of which may not make any meaningful contribution to the ethanol response under study. Here we used a novel genomic epigenetic appro

SUBMITTER: Ghezzi A 

PROVIDER: S-EPMC3861128 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature