Histopathological analysis of Salmonella chronic carriage in the mouse hepatopancreatobiliary system.

ABSTRACT: Salmonella Typhi asymptomatic chronic carriage represents a challenge for the diagnosis and prevention of typhoid fever in endemic areas. Such carriers are thought to be reservoirs for further spread of the disease. Gallbladder carriage has been demonstrated to be mediated by biofilm formation on gallstones and by intracellular persistence in the gallbladder epithelium of mice. In addition, both gallstones and chronic carriage have been associated with chronic inflammation and the development of gallbladder carcinoma. However, the pathogenic relationship between typhoid carriage and the development of pre-malignant and/or malignant lesions in the hepatopancreatobiliary system as well as the host-pathogen interactions occurring during chronic carriage remains unclear. In this study, we moni

SUBMITTER: Gonzalez-Escobedo G 

PROVIDER: S-EPMC3861519 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature