Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans.

ABSTRACT:

Objective

Although an increasing number of hypertension-associated genetic variants is being reported, replication of these findings in independent studies has been challenging. Several genes in a human chromosome 1q linkage region have been reported to be associated with hypertension. We examined polymorphisms in three of these genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans.

Methods

We genotyped 87 single nucleotide polymorphisms (SNPs) from the ATP1B1, RGS5 and SELE genes in a well characterized cohort of 968 African-Americans and performed a case-control study to identify susceptibility alleles for hypertension and blood pressure regulation. Single SNP and haplotype association testing was done under an additi

SUBMITTER: Faruque MU 

PROVIDER: S-EPMC3862027 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature