Effects of vitamin b6 therapy for sepsis patients with linezolid-associated cytopenias: a retrospective study.

ABSTRACT:

Background

The common adverse effects of linezolid for treating septic patients with gram-positive cocci is anemia and thrombocytopenia, which limit its clinical application.

Objectives

We determined the effects of vitamin B6 adjunctive therapy on linezolid-associated cytopenias, and retrospectively studied 75 septic patients who received at least 7 days of linezolid treatment.

Methods

Patients were divided into a linezolid treatment group (LTG; n = 41) that received linezolid only and a combination treatment group (CTG; n = 34) that received both linezolid and vitamin B6. Each group was further subdivided into those with sepsis and those with severe sepsis. Each patient had red blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), and platelet (PLT) measurements at ba

SUBMITTER: Deng J 

PROVIDER: S-EPMC3862191 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature