The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?

ABSTRACT: The ubiquitin/proteasome system serves as a regulated protein degradation pathway in eukaryotes, and is involved in many cellular processes featuring high protein turnover rates, such as cell cycle control, stress response and signal transduction. In malaria parasites, protein quality control is potentially important because of the high replication rate and the rapid transformations of the parasite during life cycle progression. The proteasome is the core of the degradation pathway, and is a major proteolytic complex responsible for the degradation and recycling of non-functional ubiquitinated proteins. Annotation of the genome for Plasmodium falciparum, the causative agent of malaria tropica, revealed proteins with similarity to human 26S proteasome subunits. In addition, a bacterial ClpQ

SUBMITTER: Aminake MN 

PROVIDER: S-EPMC3862440 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature