Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.

ABSTRACT:

Background

A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.

Objective

The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.

Design

Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.

Results

During 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06)

SUBMITTER: Michaelsson K 

PROVIDER: S-EPMC3862449 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature