Effective classification and gene expression profiling for the Facioscapulohumeral Muscular Dystrophy.

ABSTRACT: The Facioscapulohumeral Muscular Dystrophy (FSHD) is an autosomal dominant neuromuscular disorder whose incidence is estimated in about one in 400,000 to one in 20,000. No effective therapeutic strategies are known to halt progression or reverse muscle weakness and atrophy. It is known that the FSHD is caused by modifications located within a D4ZA repeat array in the chromosome 4q, while recent advances have linked these modifications to the DUX4 gene. Unfortunately, the complete mechanisms responsible for the molecular pathogenesis and progressive muscle weakness still remain unknown. Although there are many studies addressing cancer databases from a machine learning perspective, there is no such precedent in the analysis of the FSHD. This study aims to fill this gap by analyzing two spec

SUBMITTER: Gonzalez-Navarro FF 

PROVIDER: S-EPMC3862578 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature