A prospective study of gray matter abnormalities in mild traumatic brain injury.

ABSTRACT:

Objective

To examine the underlying pathophysiology of mild traumatic brain injury through changes in gray matter diffusion and atrophy during the semiacute stage.

Methods

Fifty patients and 50 sex-, age-, and education-matched controls were evaluated with a clinical and neuroimaging battery approximately 14 days postinjury, with 26 patients returning for follow-up 4 months postinjury. Clinical measures included tests of attention, processing speed, executive function, working memory, memory, and self-reported postconcussive symptoms. Measures of diffusion (fractional anisotropy [FA], mean diffusivity) and atrophy were obtained for cortical and subcortical structures to characterize effects of injury as a function of time.

Results

Patients reported more cognitive, som

SUBMITTER: Ling JM 

PROVIDER: S-EPMC3863349 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature