Long-term predictive value of the Framingham Risk Score for Stroke in HIV-positive vs HIV-negative men.

ABSTRACT:

Objective

To test the predictive accuracy of the Framingham Risk Score for Stroke (FRS-S) in HIV-infected (HIV+) vs HIV-uninfected (HIV-) men.

Methods

The Multicenter AIDS Cohort Study (MACS) is an ongoing prospective study of HIV+ and HIV- men who have sex with men (MSM) enrolled in 4 US cities. We ascertained all reported stroke events during a recent 15-year timeframe (July 1, 1996 to June 30, 2011) among 3,945 participants (1,776 HIV+ and 2,169 HIV-). For those with strokes, FRS-S were calculated 10 years before the stroke event and assessed according to HIV status.

Results

A total of 114 stroke events occurred, including 57 HIV+ and 37 HIV- participants with first-ever strokes and 19 fatal strokes. The incidence of first-ever stroke was 1.7/1,000 person-years amo

SUBMITTER: Mateen FJ 

PROVIDER: S-EPMC3863354 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature