Targeting loop adenines in G-quadruplex by a selective oxirane.

ABSTRACT: Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

SUBMITTER: Doria F 

PROVIDER: S-EPMC3863998 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature