Genetic variants in platelet factor 4 modulate inflammatory and platelet activation biomarkers.

ABSTRACT:

Background

African Americans suffer from higher prevalence and severity of atherosclerosis compared with whites, highlighting racial and ethnic disparities in cardiovascular disease. Previous studies have pointed to the role of vascular inflammation and platelet activation in the formation of atherosclerotic lesions.

Methods and results

We explored the role of genetic variation in 4 chemokine/chemokine receptor genes (CX3CR1, CX3CL1, CXCR3, and PF4) on systemic inflammation and platelet activation serum biomarkers (fractalkine, platelet P-selectin, platelet factor 4 [PF4], and tumor necrosis factor-α). In total, 110 single nucleotide polymorphisms were tested among 1042 African Americans and 763 whites. The strongest association with serum PF4 levels was observed for rs16844

SUBMITTER: Bhatnagar P 

PROVIDER: S-EPMC3864008 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature