HIV type 1 polymerase gene polymorphisms are associated with phenotypic differences in replication capacity and disease progression.

ABSTRACT:

Background

Determinants of intersubtype differences in human immunodeficiency virus type 1 (HIV-1) clinical disease progression remain unknown.

Methods

HIV-1 subtype was independently determined for 5 separate genomic regions in 396 HIV-1 seroconverters from Rakai, Uganda, using a multiregion hybridization assay. Replication capacities (RC) in samples from a subset of 145 of these subjects were determined. HIV-1 genomic regions and pol RC were examined for association with disease progression. Amino acid polymorphisms were examined for association with pol RC.

Results

In multivariate analyses, the hazard for progression to the composite end point (defined as a CD4(+) T-cell count <250 cells/mm(3), antiretroviral therapy initiation, or death) among patients with subtyp

SUBMITTER: Ng OT 

PROVIDER: S-EPMC3864385 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature