Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes.

ABSTRACT: Many smokers attempt to quit smoking but few are successful in the long term. The heritability of nicotine addiction and smoking relapse have been documented, and research is focused on identifying specific genetic influences on the ability to quit smoking and response to specific medications. Research in genetically modified cell lines and mice has identified nicotine acetylcholine receptor subtypes that mediate the pharmacological and behavioral effects of nicotine sensitivity and withdrawal. Human genetic association studies have identified single nucleotide polymorphisms (SNPs) in genes encoding nicotine acetylcholine receptor subunits and nicotine metabolizing enzymes that influence smoking cessation phenotypes. There is initial promising evidence for a role in smoking cessation for S

SUBMITTER: Gold AB 

PROVIDER: S-EPMC3864572 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature