Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: results from a randomized trial.

ABSTRACT:

Objective

Neonatal cardiac surgery requiring cardiopulmonary bypass results in a heightened inflammatory response. Perioperative glucocorticoid administration is commonly used in an attempt to reduce the inflammatory cascade, although characterization of the cytokine response to steroids in neonatal cardiac surgery remains elusive because of highly variable approaches in administration. This randomized trial was designed to prospectively evaluate the effect of specific glucocorticoid dosing protocols on inflammatory markers in neonatal cardiac surgery requiring cardiopulmonary bypass.

Methods

Neonates scheduled for cardiac surgery were randomly assigned to receive either 2-dose (8 hours preoperatively and operatively, n = 36) or single-dose (operatively, n = 32) methylpredni

SUBMITTER: Graham EM 

PROVIDER: S-EPMC3864609 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature