Amygdala and whole-brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder.

ABSTRACT:

Objectives

It can be clinically difficult to distinguish depressed individuals with bipolar disorder (BD) and major depressive disorder (MDD). To examine potential biomarkers of difference between the two disorders, the current study examined differences in the functioning of emotion-processing neural regions during a dynamic emotional faces task.

Methods

During functional magnetic resonance imaging, healthy control adults (HC) (n = 29) and depressed adults with MDD (n = 30) and BD (n = 22) performed an implicit emotional-faces task in which they identified a color label superimposed on neutral faces that dynamically morphed into one of four emotional faces (angry, fearful, sad, happy). We compared neural activation between the groups in an amygdala region-of-interest and at

SUBMITTER: Fournier JC 

PROVIDER: S-EPMC3864629 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature