The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome.

ABSTRACT: Sjogren's syndrome (SS) is a complex autoimmune disease that primarily affects salivary and lacrimal glands and is associated with high morbidity. Although the prevailing dogma is that immune system pathology drives SS, increasing evidence points to structural defects, including defective E-cadherin adhesion, to be involved in its etiology. We have shown that E-cadherin has pivotal roles in the development of the mouse salivary submandibular gland (SMG) by organizing apical-basal polarity in acinar and ductal progenitors and by signaling survival for differentiating duct cells. Recently, E-cadherin junctions have been shown to interact with effectors of the Hippo signaling pathway, a core pathway regulating the organ size, cell proliferation, and differentiation. We now show that Hippo sig

SUBMITTER: Enger TB 

PROVIDER: S-EPMC3864807 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature