Systemic compensatory response to neonatal estradiol exposure does not prevent depletion of the oocyte pool in the rat.

ABSTRACT: The formation of ovarian follicles is a finely tuned process that takes place within a narrow time-window in rodents. Multiple factors and pathways have been proposed to contribute to the mechanisms triggering this process but the role of endocrine factors, especially estrogens, remains elusive. It is currently hypothesized that removal from the maternal hormonal environment permits follicle formation at birth. However, experimentally-induced maintenance of high 17β-estradiol (E2) levels leads to subtle, distinct, immediate effects on follicle formation and oocyte survival depending on the species and dose. In this study, we examined the immediate effects of neonatal E2 exposure from post-natal day (PND) 0 to PND2 on the whole organism and on ovarian follicle formation in rats. Measurement

SUBMITTER: Chalmey C 

PROVIDER: S-EPMC3864944 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature