Effects of T2-Weighted MRI Based Cranial Volume Measurements on Studies of the Aging Brain.

ABSTRACT: Many brain aging studies use total intracranial volume (TIV) as a proxy measure of premorbid brain size that is unaffected by neurodegeneration. T1-weighted Magnetic Resonance Imaging (MRI) sequences are commonly used to measure TIV, but T2-weighted MRI sequences provide superior contrast between the cerebrospinal fluid (CSF) bounding the premorbid brain space and surrounding dura mater. In this study, we compared T1-based and T2-based TIV measurements to assess the practical impact of this superior contrast on studies of brain aging. 810 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants, including healthy elders and those with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), received T1-weighted and T2-weighted MRI at their baseline evaluation. TIV was automatic

SUBMITTER: Vuong P 

PROVIDER: S-EPMC3864960 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature