PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.

ABSTRACT:

Objective

Subjects with diabetes mellitus are at high risk for developing atherosclerosis through a variety of mechanisms. Because the metabolism of glucose results in production of activators of protein kinase C (PKC)β, it was logical to investigate the role of PKCβ in modulation of atherosclerosis in diabetes mellitus.

Approach and results

ApoE(-/-) and PKCβ(-/-)/ApoE(-/-) mice were rendered diabetic with streptozotocin. Quantification of atherosclerosis, gene expression profiling, or analysis of signaling molecules was performed on aortic sinus or aortas from diabetic mice. Diabetes mellitus-accelerated atherosclerosis increased the level of phosphorylated extracellular signal-regulated kinase 1/2 and Jun-N-terminus kinase mitogen-activated protein kinases and augmented v

SUBMITTER: Kong L 

PROVIDER: S-EPMC3865290 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature