Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects.

ABSTRACT:

Aim

Polymorphisms of xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on prostate cancer (PCa) risk. The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis.

Methods

Data were collected from the following electronic databases: PubMed, EMBASE, Elsevier Science Direct, Cochrane Library, and CNKI, with the last report up to April 30, 2013. Odds ratios with 95% confidence intervals were used to assess the strength of the association.

Results

A total of five separate case-control studies (1966 cases and 1970 controls) were included in this meta-analysis. Meta-analysis was performed for the rs2228001 and PAT+/-polymorphisms. We did not detect a significant association between r

SUBMITTER: Zou YF 

PROVIDER: S-EPMC3865621 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature