Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.

ABSTRACT:

Background

Many studies have examined the association between interleukin-6 (IL-6) gene polymorphisms and bone mineral density (BMD). However, the results remain conflicting. To assess the relationship more precisely, a meta-analysis was performed.

Methods

The PubMed, Embase, Chinese BioMedical Literature (CBM), Wanfang, and China National Knowledge Infrastructure (CNKI) database were searched for relevant articles published up to March 2013. Weighted mean difference (WMD) and 95% confidence interval (95% CI) were calculated using a fixed-effects or random-effects model.

Results

A total of 16 articles with 11,957 subjects were investigated in this meta-analysis. Overall, -634C/G polymorphism was significantly associated with BMD at the femoral neck (WMD, -0.016 g/cm(2

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3865625 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature