Liver injury from tumor necrosis factor-α antagonists: analysis of thirty-four cases.

ABSTRACT:

Background & aims

Tumor necrosis factor (TNF)-α antagonists have been associated with drug-induced liver injury (DILI). We reviewed cases of DILI in the United States to identify those associated with use of TNF-α antagonists.

Methods

We searched the U.S. DILI Network (DILIN) database, from 2003 to 2011, for cases associated with TNF-α antagonists. Mean Roussel-Uclaf Causality Assessment Method scores were calculated. A DILIN severity score was assigned according to a previously published scale, and we identified 6 subjects likely to have DILI associated with use of TNF-α antagonists. We also searched PubMed for articles that reported hepatotoxicity from TNF-α antagonists, identifying 28 additional cases suitable for analysis.

Results

The drugs presumed to have caused

SUBMITTER: Ghabril M 

PROVIDER: S-EPMC3865702 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature