FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney.

ABSTRACT: Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development and its inactivation results in failure of nephron progenitor cell differentiation. Foxd1 is expressed in interstitial cells adjacent to nephron progenitor cells, suggesting an essential role for the progenitor cell niche in nephrogenesis. To better understand how cortical interstitial cells in general, and FOXD1 in particular, influence the progenitor cell niche, we examined the differentiation states of two progenitor cell subtypes in Foxd1(-/-) tissue. We found that although nephron progenitor cells are retained in a primitive CITED1-expressing compartment, cortical interstitial cells prematurely differentiate. To identify pathw

SUBMITTER: Fetting JL 

PROVIDER: S-EPMC3865747 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature