Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.

ABSTRACT: Neural precursor cells of the ventricular zone give rise to all neurons and glia of the central nervous system and rely for maintenance of their precursor characteristics on the closely related SoxB1 transcription factors Sox1, Sox2 and Sox3. We show in mouse spinal cord that, whereas SoxB1 proteins are usually downregulated upon neuronal specification, they continue to be expressed in glial precursors. In the oligodendrocyte lineage, Sox2 and Sox3 remain present into the early phases of terminal differentiation. Surprisingly, their deletion does not alter precursor characteristics but interferes with proper differentiation. Although a direct influence on myelin gene expression may be part of their function, we provide evidence for another mode of action. SoxB1 proteins promote oligodendro

SUBMITTER: Hoffmann SA 

PROVIDER: S-EPMC3865748 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature