Ontology highlight
ABSTRACT:
SUBMITTER: Kearns NA
PROVIDER: S-EPMC3865759 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20140101 1
The identification of the trans-acting factors and cis-regulatory modules that are involved in human pluripotent stem cell (hPSC) maintenance and differentiation is necessary to dissect the operating regulatory networks in these processes and thereby identify nodes where signal input will direct desired cell fate decisions in vitro or in vivo. To deconvolute these networks, we established a method to influence the differentiation state of hPSCs with a CRISPR-associated catalytically inactive dCa ...[more]