Association of Barrett's esophagus with type II Diabetes Mellitus: results from a large population-based case-control study.

ABSTRACT:

Background & aims

Central obesity could increase the risk for Barrett's esophagus (BE) and esophageal adenocarcinoma by mechanical and/or metabolic mechanisms, such as hyperinsulinemia. We performed an epidemiologic study to determine whether prior type 2 diabetes mellitus (DM2) is associated with BE.

Methods

We performed a population-based case-control study using the General Practice Research Database, a UK primary care database that contains information on more than 8 million subjects, to identify cases of BE (using previously validated codes; n = 14,245) and matched controls without BE (by age, sex, enrollment date, duration of follow-up evaluation, and practice region by incidence density sampling; n = 70,361). We assessed the association of a prior diagnosis of DM2 wit

SUBMITTER: Iyer PG 

PROVIDER: S-EPMC3865768 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature