Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease.

ABSTRACT:

Background & aims

With the increasing prevalence of liver disease worldwide, there is an urgent clinical need for reliable methods to diagnose and stage liver pathology. Liver biopsy, the current gold standard, is invasive and limited by sampling and observer dependent variability. In this study, we aimed to assess the diagnostic accuracy of a novel magnetic resonance protocol for liver tissue characterisation.

Methods

We conducted a prospective study comparing our magnetic resonance technique against liver biopsy. The individual components of the scanning protocol were T1 mapping, proton spectroscopy and T2* mapping, which quantified liver fibrosis, steatosis and haemosiderosis, respectively. Unselected adult patients referred for liver biopsy as part of their routine care

SUBMITTER: Banerjee R 

PROVIDER: S-EPMC3865797 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature