A novel transcriptional mechanism of cell type-specific regulation of vascular gene expression by glucose.

ABSTRACT:

Objective

Vascular diabetic complications are associated with abnormal extracellular matrix and dysfunction of vascular cells, which later result in aberrant angiogenesis and development of atherosclerotic lesions. The tissue and cell specificity of the effects of high glucose are well recognized, but the underlying cell type-specific molecular mechanisms controlled by glucose are still unclear. We sought to identify cell type-specific mechanisms by which high glucose regulates transcription of genes in vascular cells.

Methods and results

Thrombospondin-1 is a potent antiangiogenic protein associated with development of several diabetic complications and regulated by high glucose in multiple cell types. We report that distinct cell type-specific mechanisms regulate thrombosp

SUBMITTER: Raman P 

PROVIDER: S-EPMC3865803 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature