Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.

ABSTRACT: The construction of cerebral cortex begins with the formation of radial glia. Once formed, polarized radial glial cells divide either symmetrically or asymmetrically to balance appropriate production of progenitor cells and neurons. Following birth, neurons use the processes of radial glia as scaffolding for oriented migration. Radial glia therefore provide an instructive structural matrix to coordinate the generation and placement of distinct groups of cortical neurons in the developing cerebral cortex. We found that Arl13b, a cilia-enriched small GTPase that is mutated in Joubert syndrome, was critical for the initial formation of the polarized radial progenitor scaffold. Using developmental stage-specific deletion of Arl13b in mouse cortical progenitors, we found that early neuroepithel

SUBMITTER: Higginbotham H 

PROVIDER: S-EPMC3866024 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature