An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma.

ABSTRACT:

Background

Obesity increases risk for clear-cell renal cell carcinoma (ccRCC), yet obese patients appear to experience longer survival than nonobese patients. We examined body mass index (BMI) in relation to stage, grade, and cancer-specific mortality (CSM) while considering detection bias, nutritional status, and molecular tumor features.

Methods

Data were available from 2119 ccRCC patients who underwent renal mass surgery at Memorial Sloan-Kettering Cancer Center between 1995 and 2012. Logistic regression models produced associations between BMI and advanced disease. Multivariable competing risks regression models estimated associations between BMI and CSM. Somatic mutation, copy number, methylation, and expression data were examined by BMI among a subset of 126 patients w

SUBMITTER: Hakimi AA 

PROVIDER: S-EPMC3866155 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature