Disrupted topological organization in whole-brain functional networks of heroin-dependent individuals: a resting-state FMRI study.

ABSTRACT: Neuroimaging studies have shown that heroin addiction is related to abnormalities in widespread local regions and in the functional connectivity of the brain. However, little is known about whether heroin addiction changes the topological organization of whole-brain functional networks. Seventeen heroin-dependent individuals (HDIs) and 15 age-, gender-matched normal controls (NCs) were enrolled, and the resting-state functional magnetic resonance images (RS-fMRI) were acquired from these subjects. We constructed the brain functional networks of HDIs and NCs, and compared the between-group differences in network topological properties using graph theory method. We found that the HDIs showed decreases in the normalized clustering coefficient and in small-worldness compared to the NCs. Furthe

SUBMITTER: Jiang G 

PROVIDER: S-EPMC3866189 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature