Outpatient calcium-channel blockers and the risk of postpartum haemorrhage: a cohort study.

ABSTRACT:

Objective

To determine whether outpatient exposure to calcium-channel blockers (CCBs) at the time of delivery is associated with an increased risk for postpartum haemorrhage (PPH).

Design

Cohort study.

Setting

United States of America.

Population or sample

Medicaid beneficiaries.

Methods

We identified a cohort of 9750 patients with outpatient prescriptions for CCBs, methyldopa, or labetalol for pre-existing or gestational hypertension whose days of supply overlapped with delivery; 1226 were exposed to CCBs. The risk of PPH was compared in those exposed to CCBs to those exposed to methyldopa or labetalol. Propensity score matching and stratification were used to address potential confounding.

Main outcome measures

The occurrence of PPH during the d

SUBMITTER: Bateman BT 

PROVIDER: S-EPMC3866215 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature