Ontology highlight
ABSTRACT:
SUBMITTER: Sampson TR
PROVIDER: S-EPMC3866243 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Sampson Timothy R TR Weiss David S DS
RNA biology 20130920 10
CRISPR/Cas systems are bacterial RNA-guided endonuclease machineries that target foreign nucleic acids. Recently, we demonstrated that the Cas protein Cas9 controls gene expression and virulence in Francisella novicida by altering the stability of the mRNA for an immunostimulatory bacterial lipoprotein (BLP). Genomic analyses, however, revealed that Francisella species with increased virulence harbor degenerated CRISPR/Cas systems. We hypothesize that CRISPR/Cas degeneration removed a barrier ag ...[more]