Sequence divergence and conservation in genomes of Helicobacter cetorum strains from a dolphin and a whale.

ABSTRACT:

Background and objectives

Strains of Helicobacter cetorum have been cultured from several marine mammals and have been found to be closely related in 16 S rDNA sequence to the human gastric pathogen H. pylori, but their genomes were not characterized further.

Methods

The genomes of H. cetorum strains from a dolphin and a whale were sequenced completely using 454 technology and PCR and capillary sequencing.

Results

These genomes are 1.8 and 1.95 mb in size, some 7-26% larger than H. pylori genomes, and differ markedly from one another in gene content, and sequences and arrangements of shared genes. However, each strain is more related overall to H. pylori and its descendant H. acinonychis than to other known species. These H. cetorum strains lack cag pathogenicity isla

SUBMITTER: Kersulyte D 

PROVIDER: S-EPMC3866246 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature